Removal of vaccinia virus genes that block interferon type I and II pathways improves adaptive and memory responses of the HIV/AIDS vaccine candidate NYVAC-C in mice.
Via Scoop.it – Virology and Bioinformatics from Virology.ca
Poxviruses encode multiple inhibitors of the interferon (IFN) system, acting at different levels and blocking the induction of host defence mechanisms. Two viral gene products B19 and B8 have been shown to act as decoy receptors of type I and type II IFN, blocking the binding of IFN to its receptor.
