Design of Potent Poxvirus Inhibitors of the Heterodimeric Processivity Factor [J Med Chem. 2013] –
See on Scoop.it – Virology and Bioinformatics from Virology.ca
Smallpox constitutes a major bioterrorism threat, which underscores the need to develop antiviral drugs for rapid response in the event of an attack. Viral processivity factors are attractive drug targets in being both specific and essential for their cognate DNA polymerases to synthesize extended strands of DNA. An in silico model of the vacinnia virus processivity factor, comprised of the A20 and D4 heterocomplex, was constructed and used for lead optimization of an indole-based scaffold identified earlier from a high-throughput screening.
See on www.ncbi.nlm.nih.gov
