BMC Research Notes | Abstract | DivA: detection of non-homologous and very divergent regions in protein sequence alignments
Sequence alignments are used to find evidence of homology but sometimes contain regions that are difficult to align which can interfere with the quality of the subsequent analyses. Although it is possible to remove problematic regions manually, this is non-practical in large genome scale studies, and the results suffer from irreproducibility arising from subjectivity. Some automated alignment trimming methods have been developed to remove problematic regions in alignments but these mostly act by removing complete columns or complete sequences from the MSA, discarding a lot of informative sites.
Source: www.biomedcentral.com
See on Scoop.it – Virology and Bioinformatics from Virology.ca
