Use of AAScatterPlot tool for monitoring the evolution of hemagglutinin cleavage site in H9 avian viruses
Given genome sequences, the AAScatterPlot tool compacts into a single plot, information about the hydropathy index, Van der Waals volume, chemical property, and occurrence frequency of amino acid residues. The tool also shows the range of residues that could arise from a single point mutation in the genome, which can then be compared against the observed residues to identify mutation constraints. Through this approach, we found that the 2 nd position towards the N-terminus side of the HA PCS (P2 position) avoided hydrophobic residues, whereas the P3 position avoided hydrophilic residues. AAScatterPlot is available at https://github.com/WhittakerLab/AAScatterPlot.See it on Scoop.it, via Viruses and Bioinformatics from Virology.uvic.ca
Use of AAScatterPlot tool for monitoring the evolution of hemagglutinin cleavage site in H9 avian viruses
Source: Viral Bioinformatics
