Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases
Highlights• Crystal and cryo-EM structures of NSV polymerases influenza, La Crosse and VSV.• Segmented and non-segmented NSV polymerases have a similar extended core architecture.• Influenza and LACV structures show how the vRNA promoter is bound.• The cap-snatching mechanism of influenza polymerase (sNSV) is explained.• VSV (nsNSV) capping domains block product exit and thus need to rearrange.• Separate exit channels for template and product allow replication within the RNP context.See it on Scoop.it, via Viruses and Bioinformatics from Virology.uvic.ca
Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases
Source: Viral Bioinformatics
