Deciphering the Human Virome with Single-Virus Genomics and Metagenomics

Single-cell genomics has unveiled the metabolic potential of dominant microbes inhabiting different environments, including the human body. The lack of genomic information for predominant microbes of the human body, such as bacteriophages, hinders our ability to answer fundamental questions about our viral communities. Here, we applied single-virus genomics (SVGs) to natural human salivary samples in combination with viral metagenomics to gain some insights into the viral community structure of the oral cavity.  Results suggest a variable, complex, and interpersonal viral profile. Finally, we demonstrated the power of SVGs in combination with viral metagenomics to unveil the genetic information of the uncultured viruses of the human virome.See it on Scoop.it, via Viruses, Immunology & Bioinformatics from Virology.uvic.ca
Deciphering the Human Virome with Single-Virus Genomics and Metagenomics
Source: Viral Bioinformatics