Identification of putative promoters in 48 eukaryotic genomes on the basis of DNA free energy

The cognate motifs in the promoters are observed in only a subset of total genes across different domains of life. Hence, sequence-motif based promoter prediction may not be a holistic approach for whole genomes. Conversely, the DNA structural property, duplex stability is a characteristic of promoters and can be used to delineate them from other genomic sequences. In this study, we have used a DNA duplex stability based algorithm ‘PromPredict’ for promoter prediction in a broad range of eukaryotes, representing various species of yeast, worm, fly, fish, and mammal. Efficiency of the software has been tested in promoter regions of 48 eukaryotic systems. PromPredict achieves recall values, which range from 68 to 92% in various eukaryotes. See it on Scoop.it, via Viruses, Immunology & Bioinformatics from Virology.uvic.ca
Identification of putative promoters in 48 eukaryotic genomes on the basis of DNA free energy
Source: Viral Bioinformatics