Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells
Highlights •HIV-1-infected CD4+ T cells activate cellular survival programs •CD4+ T cells upregulate BIRC5 and OX40 during latent and productive HIV-1 infection •OX40+CD4+ T cells from ART-treated patients are enriched for clonal HIV-1 sequences •Inhibition of BIRC5 reduces the frequency of CD4+ T cells encoding for intact HIV-1See it on Scoop.it, via Viruses, Immunology & Bioinformatics from Virology.uvic.ca
Anti-apoptotic Protein BIRC5 Maintains Survival of HIV-1-Infected CD4+ T Cells
Source: Viral Bioinformatics
