Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation
Poxviruses are double-stranded DNA viruses replicating in the cytosol and hence likely to trigger cytosolic DNA sensing. Here, we investigated the activation of innate immune signaling by 4 different strains of the prototypic poxvirus vaccinia virus (VACV) in a cell line proficient in DNA sensing. Infection with the attenuated VACV strain MVA activated IRF-3 via cGAS and STING, and accordingly STING dimerized and was phosphorylated during MVA infection. Conversely, VACV strains Copenhagen and Western Reserve inhibited STING dimerization and phosphorylation during infection and in response to transfected DNA and cyclic GMP-AMP, thus efficiently suppressing DNA sensing and IRF-3 activation.See it on Scoop.it, via Viruses, Immunology & Bioinformatics from Virology.uvic.ca
Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation
Source: Viral Bioinformatics
