Zika enhancement: a reality check

In northeast Brazil, dengue seropositivity is high but is not homogenous in the population.14 It is not known whether cases of congenital Zika syndrome occurred preferentially in women with previous dengue infection or whether cases cluster in regions with greater dengue seropositivity. Additionally, the situation might be much more complex because of the presence of yellow fever vaccination in the area. A spatial analysis study15 showed that the risk of congenital Zika syndrome in northeast Brazil clustered in regions where yellow fever vaccination rates were the lowest. Epidemiological evidence correlating sequential dengue virus–Zika virus infections in individuals with different Zika virus clinical syndromes compared with matched controls should be sought expeditiously. Dengue virus ADE of Zika virus infections, if real, will have profound implications for the design, testing, and delivery of Zika virus and dengue virus vaccines.

Zika enhancement: a reality check
Source: Virology News