Tricks an IRES uses to enslave ribosomes. [Trends Microbiol. 2012] – PubMed – NCBI
See on Scoop.it – Virology and Bioinformatics from Virology.ca
In eukaryotes, mRNAs are primarily translated through a cap-dependent mechanism whereby initiation factors recruit the 40S ribosomal subunit to a cap structure at the 5′ end of the mRNA. However, some viral and cellular messages initiate protein synthesis without a cap. They use a structured RNA element termed an internal ribosome entry site (IRES) to recruit the 40S ribosomal subunit. IRESs were discovered over 20 years ago, but only recently have studies using a model IRES from dicistroviruses expanded our understanding of how a 3D RNA structure can capture and manipulate the ribosome to initiate translation.
See on www.ncbi.nlm.nih.gov
