Structural Mechanism of ER Retrieval of MHC Class I by Cowpox
See on Scoop.it – Virology and Bioinformatics from Virology.ca
One of the hallmarks of viral immune evasion is the capacity to disrupt major histocompatibility complex class I (MHCI) antigen presentation to evade T-cell detection. Cowpox virus encoded protein CPXV203 blocks MHCI surface expression by exploiting the KDEL-receptor recycling pathway, and here we show that CPXV203 directly binds a wide array of fully assembled MHCI proteins, both classical and non-classical.
See on www.plosbiology.org
