The Choreography of HIV-1 Proteolytic Processing and Virion Assembly
See on Scoop.it – Virology and Bioinformatics from Virology.ca
I thank Russell Kightley Media for the HIV matrix graphic
"For HIV-1, the Gag protein has the role of a polyprotein precursor that contains all of the structural proteins of the virion, Matrix (MA), Capsid (CA), Spacer Peptide 1 (SP1), Nucleocapsid (NC), Spacer Peptide 2 (SP2), and p6 which contains protein binding domains that interact with host proteins during budding. Similarly, the Gag-Pro-Pol precursor encodes most of the Gag protein but now includes the viral enzymes: protease (PR), reverse transcriptase (RT, with its associated RNase H activity), and integrase (IN). Gag and Gag-Pro- Pol are the substrates of the viral PR, which is responsible for cleaving these precursors into their mature and fully active forms."
Great paper – explains a complicated process very well.
See on intl.jbc.org
