PLOS Pathogens: The Spatial Organization of DNA Virus Genomes in the Nucleus
See on Scoop.it – Virology and Bioinformatics from Virology.ca
During lytic infection, DNA viruses that replicate in the nucleus of cells establish an environment that favors viral replication while evading cellular defenses. Consequently, these viruses must engage with cellular factors that are necessary for efficient viral transcription and DNA replication, while disarming restrictive cellular responses to the presence of the invading pathogenic DNA. It is important to consider these events not only at the biochemical level of protein-protein and protein-nucleic acid interactions, but also in terms of spatial organization within the nucleus.
See on www.plospathogens.org
