Evolutionary footprint of coevolving positions in genes
See on Scoop.it – Virology and Bioinformatics from Virology.ca
Motivation: The analysis of molecular coevolution provides information on the potential functional and structural implication of positions along DNA sequences, and several methods are available to identify coevolving positions using probabilistic or combinatorial approaches. The specific nucleotide or amino acid profile associated with the coevolution process is, however, not estimated, but only known profiles, such as the Watson–Crick constraint, are usually considered a priori in current measures of coevolution.
