Tabhu: tools for antibody humanization. – PubMed – NCBI
Bioinformatics. 2015 Feb 1;31(3):434-5. doi: 10.1093/bioinformatics/btu667. Epub 2014 Oct 9.
Source: www.ncbi.nlm.nih.gov
Antibodies are rapidly becoming essential tools in the clinical practice, given their ability to recognize their cognate antigens with high specificity and affinity, and a high yield at reasonable costs in model animals. Unfortunately, when administered to human patients, xenogeneic antibodies can elicit unwanted and dangerous immunogenic responses. Antibody humanization methods are designed to produce molecules with a better safety profile still maintaining their ability to bind the antigen.
See on Scoop.it – Virology and Bioinformatics from Virology.ca
