Automatic Prediction of Protein 3D Structures by Probabilistic Multi-template Homology Modeling

Author Summary Since a protein’s function is largely determined by its structure, predicting a protein’s structure from its amino acid sequence can be very useful to understand its molecular functions and its role in biological pathways. By far the most widely used computational approach for protein structure prediction relies on detecting a homologous relationship with a protein of known structure and using this protein as a template to model the structure of the query protein on it. The bas

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